The Laboratory for Developmental Genetics at the University
of Southern California has confirmed cytomegalovirus (CMV) as a cause of the
most common salivary gland cancers. The
findings, published in the journal Experimental and Molecular Pathology, are
the latest in a series of studies by USC researchers that together demonstrate
CMV's role as an oncovirus, a virus that can either trigger cancer in healthy
cells or exploit mutant cell weaknesses to enhance tumor formation.[1]
Researcher and author Michael Melnick, professor of
developmental genetics in the Ostrow School of Dentistry of USC, said the
conclusion that CMV is an oncovirus came after rigorous study of both human
salivary gland tumors and salivary glands of postnatal mice. This study illustrates not only that the CMV
in the tumors is active but also that the amount of virus-created proteins
found is positively correlated with the severity of the cancer.[2]
This should be a most productive area of investigation for a
long time to come. April is Oral Cancer
Awareness Month and we offer free examinations.
Please give us a call and make an appointment.
Novy Scheinfeld, DDS, PC
290 Carpenter Drive, 200A
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[1] "Human Cytomegalovirus and Mucoepidermoid Carcinoma of Salivary Glands: Cell-Specific Localization of Active Viral and Oncogenic Signaling Proteins is Confirmatory of a Causal Relationship," was funded by the Oral Biology Fund of the Ostrow School of Dentistry of USC.
[2] Ibid.
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